Slow-growing lambdoid melanotic neuroectodermal tumor of infancy
Nat Rev Mol Cell Biol 14, 133139, 10.1038/nrm3522 (2013)
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For the 5 mg/kg IP injection, the estimated mean AUC by 3 h (AUC 03hr ) was 20.4 mgmin/mL, which accounted for more than 95% of the estimated total AUC (AUC 0- ) of 21.0 mgmin/mL
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The primary outcome is to identify the maximum dose tolerated, and the second aim is to evaluate neurological outcome
